Elimite (Permethrin)

Elimite Review

Elimite is used for the treatment of scabies.

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Elimite Drug Class and Mechanism

Permethrin is a common synthetic chemical, widely used as an insecticide and acaricide and as an insect repellent. It belongs to the family of synthetic chemicals called pyrethroids and functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation. It is not known to harm most mammals or birds. It generally has a low mammalian toxicity and is poorly absorbed by skin.

Elimite Uses

In agriculture, permethrin is mainly used on cotton, wheat, maize, and alfalfa crops, and is also used to kill parasites on chickens and other poultry. It is also extensively used in Europe as a timber treatment against wood boring beetle (woodworm). Its use is controversial since, as a broad-spectrum chemical, it kills indiscriminately; as well as the intended pests, it can harm beneficial insects including honey bees, aquatic life, and small mammals such as mice. Permethrin is toxic to cats and many cats die each year after being given flea treatments intended for dogs, or by contact with dogs who have recently been treated with permethrin. However, permethrin can be used in a targeted manner as well. This is the basis for a method of reducing populations of the deer tick Ixodes scapularis (I. dammini). Biodegradable cardboard tubes stuffed with permethrin-treated cotton, are sold under the brand name Damminix, Mice collect the cotton for lining their nests, and the pesticide on the cotton kills any immature ticks that are feeding on the mice. Permethrin is also used in healthcare, to eradicate parasites such as head lice and mites responsible for scabies, and in industrial and domestic settings to control pests such as ants and termites. Permethrin kills ticks on contact with treated clothing. According to the Connecticut Department of Public Health, it "has low mammalian toxicity, is poorly absorbed through the skin and is rapidly inactivated by the body. Skin reactions have been uncommon."Permethrin is used in tropical areas to prevent mosquito-borne disease such as dengue fever and malaria. Mosquito nets used to cover beds may be treated with a solution of permethrin. This increases the effectiveness of the bed net by killing parasitic insects before they are able to find gaps or holes in the net. Malaria kills 1-3 million people per year, and permethrin is believed to have very low if any toxicity in humans. Military personnel training in malaria-endemic areas may be instructed to treat their uniforms with permethrin as well. An application should last several washes.Adults and children: Thoroughly massage ELIMITE® into the skin from the head to the soles of the feet. Scabies rarely infests the scalp of adults, although the hairline, neck, temple, and forehead may be infested in infants and geriatric patients. Usually 30 grams is sufficient for an average adult. The cream should be removed by washing (shower or bath) after 8 to 14 hours.

Elimite Side Effects

In clinical trials, generally mild and transient burning and stinging followed application with ELIMITE® in 10% of patients and was associated with the severity of infestation. Pruritus was reported in 7% of patients at various times post-application. Erythema, numbness, tingling, and rash were reported in 1 to 2% or less of patients

Elimite Pregnancy

Elimite Overdose

No instance of accidental ingestion of ELIMITE® has been reported. If ingested, gastric lavage and general supportive measures should be employed.

Elimite More Information

To prevent reinfection, thoroughly wash all clothing, hats, bed clothes, bed linens, hair brushes, or combs that might have been previously infected.